• About TC
  • Affiliate Disclaimer
  • Privacy Policy
  • TOS
  • Contact
Tuesday, July 29, 2025
Techcratic
No Result
View All Result
  • AI
    Artificial Intelligence

    Amazon Nova Act SDK (preview): Path to production for browser automation agents

    Artificial Intelligence

    Benefits of Using LiteLLM for Your LLM Apps

    Artificial Intelligence

    5 Fun Generative AI Projects for Absolute Beginners

    Artificial Intelligence

    Vibe Coding Something Useful with Repl.it

    Artificial Intelligence

    Use generative AI in Amazon Bedrock for enhanced recommendation generation in equipment…

    Artificial Intelligence

    The Lifecycle of Feature Engineering: From Raw Data to Model-Ready Inputs

    Artificial Intelligence

    Building End-to-End Data Pipelines: From Data Ingestion to Analysis

    Artificial Intelligence

    How Rapid7 automates vulnerability risk scores with ML pipelines using Amazon SageMaker AI

    Artificial Intelligence

    Build a conversational data assistant, Part 2 – Embedding generative business intelligence with Amazon Q in QuickSight

  • Apple
    ESR MagMouse review: a wireless mouse that sticks to your MacBook

    ESR MagMouse review: a wireless mouse that sticks to your MacBook

    Here’s a first look at the new M4 MacBook Air in sky blue

    M4 MacBook Air’s biggest success may still be ahead of it

    M4 MacBook Air, MacBook Pro, Apple Watch Ultra 2, more 9to5Mac

    M4 MacBook Air, MacBook Pro, Apple Watch Ultra 2, more 9to5Mac

    bitchat mesh, Jack Dorsey’s messaging app debuts on the App Store

    bitchat mesh, Jack Dorsey’s messaging app debuts on the App Store

    Here’s everything new for the Messages app in iOS 26

    Here’s everything new for the Messages app in iOS 26

    In a first for the country, Apple to close Parkland Mall store in China

    In a first for the country, Apple to close Parkland Mall store in China

    Did someone just get caught using the iPhone 17 Pro in the wild?

    Did someone just get caught using the iPhone 17 Pro in the wild?

    Apple’s AI glasses are coming sooner than we thought

    Ray-Ban Meta smart glasses sales triples in the last year

    Message filtering in iOS 26 upsetting politicians

    Message filtering in iOS 26 upsetting politicians

  • ComputerWorld
    Alibaba unveils AI-powered smart glasses

    Alibaba unveils AI-powered smart glasses

    Why firewalls and VPN are bad for security

    Why firewalls and VPN are bad for security

    Leena AI unveils conversational AI ‘colleagues’ for the enterprise

    Leena AI unveils conversational AI ‘colleagues’ for the enterprise

    IT buyers are investing in AI PCs — with no clue how to use them

    IT buyers are investing in AI PCs — with no clue how to use them

    Apple wants to build a circular manufacturing economy

    Apple wants to build a circular manufacturing economy

    Trump gets aggressive with new US AI action plan

    Trump gets aggressive with new US AI action plan

    Clorox sues Cognizant for $380M over alleged helpdesk failures in cyberattack

    Clorox sues Cognizant for $380M over alleged helpdesk failures in cyberattack

    Kandji helps secure Apple enterprise with Vulnerability Response

    Kandji helps secure Apple enterprise with Vulnerability Response

    Alibaba rolls out new AI coding model Qwen3-Coder, says it’s their most powerful

    Alibaba rolls out new AI coding model Qwen3-Coder, says it’s their most powerful

  • Gaming
    How to get the corrupt mutation in Grow a Garden

    How to get the corrupt mutation in Grow a Garden

    Is Gotham Knights As Bad As You Think?

    Is Gotham Knights As Bad As You Think?

    Stage 12 – Gungrave G.O.R.E PS5

    Stage 12 – Gungrave G.O.R.E PS5

    SUPER MARIO 3D WORLD – Trailer (Wii U)

    SUPER MARIO 3D WORLD – Trailer (Wii U)

    Assassin’s Creed : All Opening Title Intros (2007-2023)

    Assassin’s Creed : All Opening Title Intros (2007-2023)

    How this Film could be Incredible!!! | Super Mario Bros. Movie HOPES!

    How this Film could be Incredible!!! | Super Mario Bros. Movie HOPES!

    Hogwarts Legacy Review: Is it Worth the Hype?

    Hogwarts Legacy Review: Is it Worth the Hype?

    The Legion Go S SteamOS is completing the Steam Deck’s mission to make handheld PC gaming genuinely convenient

    Some lucky souls will get hands-on with Silksong within weeks, with the Hollow Knight sequel confirmed to be playable at Gamescom 2025

    The Division 2: Battle for Brooklyn DLC & Year 7 Showcase

    The Division 2: Battle for Brooklyn DLC & Year 7 Showcase

  • Retro Rewind
    Retro Rewind: Video Game Trader Winter 2014

    Retro Rewind: Video Game Trader Winter 2014

    Retro Rewind: Electronic Games April 1995

    Retro Rewind: Electronic Games April 1995

    Retro Rewind: Electronic Gaming Monthly Magazine Number 55 February 1994

    Retro Rewind: Electronic Gaming Monthly Magazine Number 57 April 1994

    Retro Rewind: Blast from the Past – 35 Iconic Commercials of 1988!

    Retro Rewind: Blast from the Past – 35 Iconic Commercials of 1988!

    Retro Rewind: PC World Magazine August 1998

    Retro Rewind: PC World Magazine August 1998

    Retro Rewind: Computer Shopper Magazine September 1997

    Retro Rewind: Computer Shopper Magazine September 1997

    Retro Rewind: PC Magazine December 2015

    Retro Rewind: PC Magazine December 2015

    Retro Rewind: EDGE Magazine RETRO #1: The Guide to Classic Videogame Playing and Collecting

    Retro Rewind: EDGE Magazine RETRO #1: The Guide to Classic Videogame Playing and Collecting

    Retro Rewind: Computer Gaming World Magazine Issue 73 December 1998

    Retro Rewind: Computer Gaming World Magazine Issue 73 December 1998

  • Tech Art
    3d spray wall painting flowers design || 3d wall paper wall painting || Freestyle artist sourav

    3d spray wall painting flowers design || 3d wall paper wall painting || Freestyle artist sourav

    03 EPIC Graphic Design Ideas in Photoshop – Full Tutorial

    03 EPIC Graphic Design Ideas in Photoshop – Full Tutorial

    How I Create AI Vector Files for Microstock | Step-by-Step for Adobe Stock & More

    How I Create AI Vector Files for Microstock | Step-by-Step for Adobe Stock & More

    5 Minute Drawing Lesson – digital illustration process explained

    5 Minute Drawing Lesson – digital illustration process explained

    How To Find Your Art Style (4 EASY WAYS) | Art Tips

    How To Find Your Art Style (4 EASY WAYS) | Art Tips

    Sarah D’Ambrosio: Brooklyn, Berlin

    Sarah D’Ambrosio: Brooklyn, Berlin

    WOOFIE SAD ORIGIN STORY?! The Amazing Digital Circus UNOFFICIAL Animation

    WOOFIE SAD ORIGIN STORY?! The Amazing Digital Circus UNOFFICIAL Animation

    Augmented Reality Fun with DoodleLens & PowerPoint

    Augmented Reality Fun with DoodleLens & PowerPoint

    Vector Art/ Vector Portrait Cartoon Effect Photoshop Action free Download

    Vector Art/ Vector Portrait Cartoon Effect Photoshop Action free Download

  • Tech Deals
    Western Digital 1TB WD Blue 3D NAND Internal PC SSD – SATA III 6 Gb/s, 2.5″/7mm, Up to…

    Western Digital 1TB WD Blue 3D NAND Internal PC SSD – SATA III 6 Gb/s, 2.5″/7mm, Up to…

    ICY BOX M.2 NVMe & SATA SSD/HDD Docking Station, USB-C 10 Gbps Dual Bay Hard Drive Clone…

    ICY BOX M.2 NVMe & SATA SSD/HDD Docking Station, USB-C 10 Gbps Dual Bay Hard Drive Clone…

    Apple iPad with WiFi, 32GB, Silver (2017 Model) (Renewed)

    Apple iPad with WiFi, 32GB, Silver (2017 Model) (Renewed)

    Veken 55 Inch Large Electric Standing Desk, 4 Memory Heights Adjustable,Sit to Stand Up,…

    Veken 55 Inch Large Electric Standing Desk, 4 Memory Heights Adjustable,Sit to Stand Up,…

    SM600 White Wireless Gaming Mouse,8000 DPI Tri-Modes BT5.1/Type-C Wired/2.4G Wireless…

    SM600 White Wireless Gaming Mouse,8000 DPI Tri-Modes BT5.1/Type-C Wired/2.4G Wireless…

    GTRACING Gaming Chair Racing Office Computer Ergonomic Video Game Chair Backrest and…

    GTRACING Gaming Chair Racing Office Computer Ergonomic Video Game Chair Backrest and…

    Rock Band – Nintendo Wii (Game only) (Renewed)

    Rock Band – Nintendo Wii (Game only) (Renewed)

    SanDisk 512GB Ultra Fit USB 3.2 Gen 1 Flash Drive – Up to 400MB/s, Plug-and-Stay Design…

    SanDisk 512GB Ultra Fit USB 3.2 Gen 1 Flash Drive – Up to 400MB/s, Plug-and-Stay Design…

    WD_BLACK 5TB P10 Game Drive, Portable External Hard Drive, Works with Playstation, Xbox,…

    WD_BLACK 5TB P10 Game Drive, Portable External Hard Drive, Works with Playstation, Xbox,…

  • Techs Got To Eat
    Strawberry Shortcake Mug Cake: In Minutes Your Summer Bliss Dessert

    Strawberry Shortcake Mug Cake: In Minutes Your Summer Bliss Dessert

    Molten Bacon Lasagna Mug: Crispy, Cheesy & Ready In 5 Minutes

    Molten Bacon Lasagna Mug: Crispy, Cheesy & Ready In 5 Minutes

    Bacon & Spinach Mug Quiche: 3-Minute Gourmet Breakfast

    Bacon & Spinach Mug Quiche: 3-Minute Gourmet Breakfast

    Cheesy Broccoli Rice Mug: 5-Minute Super Comfort Food

    Cheesy Broccoli Rice Mug: 5-Minute Super Comfort Food

    Top 10 Vegetarian Recipes for 2025: Easy and Nutritious Meals for Busy People

    Top 10 Vegetarian Recipes for 2025: Easy and Nutritious Meals for Busy People

    Bacon Mug Lasagna: 5-Minute Microwave Meat Lover’s Dream

    Bacon Mug Lasagna: 5-Minute Microwave Meat Lover’s Dream

    Bacon Fried Rice Mug: 5-Minute Microwave Meal

    Bacon Fried Rice Mug: 5-Minute Microwave Meal

    Bacon & Cheddar Mug Biscuit: 2-Minute Savory Comfort

    Bacon & Cheddar Mug Biscuit: 2-Minute Savory Comfort

    Loaded Bacon Cheesy Potato Mug: 5-Minute Comfort Food

    Loaded Bacon Cheesy Potato Mug: 5-Minute Comfort Food

  • Tesla
    BestEvMod 13PCS Speaker Cover Trim Kits Compatible with Tesla Cybertruck 2025 2024…

    BestEvMod 13PCS Speaker Cover Trim Kits Compatible with Tesla Cybertruck 2025 2024…

    Cartist Dash Cover Fit for Tesla Cybertruck 2024 2025 2026 Accessories Dashboard Cover…

    Cartist Dash Cover Fit for Tesla Cybertruck 2024 2025 2026 Accessories Dashboard Cover…

    Car Phone Holder, Car Center Console Dashboard Mobile Phone Holder, for Various…

    Car Phone Holder, Car Center Console Dashboard Mobile Phone Holder, for Various…

    2-in-1 CCS & J1772 to Tesla Adapter – 250KW Fast CCS to Tesla Adapter, Compatible with…

    2-in-1 CCS & J1772 to Tesla Adapter – 250KW Fast CCS to Tesla Adapter, Compatible with…

    TANDRIVE 2PCS Silicone Key Card Holder Case Compatible with Tesla Model 3 Model Y…

    TANDRIVE 2PCS Silicone Key Card Holder Case Compatible with Tesla Model 3 Model Y…

    Schumacher Electric SC1455 Level 2 Portable EV Charger – up to 16A, Works with 120V or 2…

    Schumacher Electric SC1455 Level 2 Portable EV Charger – up to 16A, Works with 120V or 2…

    Tesla inks $16.5B deal with Samsung for HW6 chips, but still no HW3 solution

    Tesla inks $16.5B deal with Samsung for HW6 chips, but still no HW3 solution

    2025 Upgraded for Tesla Supercharger to CCS Charger Adapter, Max 500A 1000V Fast Charge…

    2025 Upgraded for Tesla Supercharger to CCS Charger Adapter, Max 500A 1000V Fast Charge…

    Door Built-in Hidden Storage Box for Tesla Cybertruck 2024, Pop-Up Lid Door Side…

    Door Built-in Hidden Storage Box for Tesla Cybertruck 2024, Pop-Up Lid Door Side…

  • UFO
    Resident Alien: Season Two [DVD]

    Resident Alien: Season Two [DVD]

    Photoshop: How to Recreate a Vintage, UFO Sighting Photo!

    Photoshop: How to Recreate a Vintage, UFO Sighting Photo!

    UFO Encounters & Religion: Unexpected Spiritual Reinforcement

    UFO Encounters & Religion: Unexpected Spiritual Reinforcement

    GXCROR Sports Sun Visor Hat Men Women, Lightweight Breathable Quick-Dry Visor Hat, UPF 50+ Tennis Golf Running Visor

    GXCROR Sports Sun Visor Hat Men Women, Lightweight Breathable Quick-Dry Visor Hat, UPF 50+ Tennis Golf Running Visor

    UFOs Over Washington, D.C. (1952): The 'Invasion' That Shook the Nation

    UFOs Over Washington, D.C. (1952): The 'Invasion' That Shook the Nation

    UFOs: The Public Deceived

    UFOs: The Public Deceived

    Scientists Believe This Is an Alien?!

    Scientists Believe This Is an Alien?!

    Quetzalcoatl's True Origins | Ancient Aliens | #shorts

    Quetzalcoatl's True Origins | Ancient Aliens | #shorts

    FIRST CONTACTEE TRAINING WITH RIOK, ALAN STEINFELD, – ESP, Remote viewing, Channeling

    FIRST CONTACTEE TRAINING WITH RIOK, ALAN STEINFELD, – ESP, Remote viewing, Channeling

  • AI
    Artificial Intelligence

    Amazon Nova Act SDK (preview): Path to production for browser automation agents

    Artificial Intelligence

    Benefits of Using LiteLLM for Your LLM Apps

    Artificial Intelligence

    5 Fun Generative AI Projects for Absolute Beginners

    Artificial Intelligence

    Vibe Coding Something Useful with Repl.it

    Artificial Intelligence

    Use generative AI in Amazon Bedrock for enhanced recommendation generation in equipment…

    Artificial Intelligence

    The Lifecycle of Feature Engineering: From Raw Data to Model-Ready Inputs

    Artificial Intelligence

    Building End-to-End Data Pipelines: From Data Ingestion to Analysis

    Artificial Intelligence

    How Rapid7 automates vulnerability risk scores with ML pipelines using Amazon SageMaker AI

    Artificial Intelligence

    Build a conversational data assistant, Part 2 – Embedding generative business intelligence with Amazon Q in QuickSight

  • Apple
    ESR MagMouse review: a wireless mouse that sticks to your MacBook

    ESR MagMouse review: a wireless mouse that sticks to your MacBook

    Here’s a first look at the new M4 MacBook Air in sky blue

    M4 MacBook Air’s biggest success may still be ahead of it

    M4 MacBook Air, MacBook Pro, Apple Watch Ultra 2, more 9to5Mac

    M4 MacBook Air, MacBook Pro, Apple Watch Ultra 2, more 9to5Mac

    bitchat mesh, Jack Dorsey’s messaging app debuts on the App Store

    bitchat mesh, Jack Dorsey’s messaging app debuts on the App Store

    Here’s everything new for the Messages app in iOS 26

    Here’s everything new for the Messages app in iOS 26

    In a first for the country, Apple to close Parkland Mall store in China

    In a first for the country, Apple to close Parkland Mall store in China

    Did someone just get caught using the iPhone 17 Pro in the wild?

    Did someone just get caught using the iPhone 17 Pro in the wild?

    Apple’s AI glasses are coming sooner than we thought

    Ray-Ban Meta smart glasses sales triples in the last year

    Message filtering in iOS 26 upsetting politicians

    Message filtering in iOS 26 upsetting politicians

  • ComputerWorld
    Alibaba unveils AI-powered smart glasses

    Alibaba unveils AI-powered smart glasses

    Why firewalls and VPN are bad for security

    Why firewalls and VPN are bad for security

    Leena AI unveils conversational AI ‘colleagues’ for the enterprise

    Leena AI unveils conversational AI ‘colleagues’ for the enterprise

    IT buyers are investing in AI PCs — with no clue how to use them

    IT buyers are investing in AI PCs — with no clue how to use them

    Apple wants to build a circular manufacturing economy

    Apple wants to build a circular manufacturing economy

    Trump gets aggressive with new US AI action plan

    Trump gets aggressive with new US AI action plan

    Clorox sues Cognizant for $380M over alleged helpdesk failures in cyberattack

    Clorox sues Cognizant for $380M over alleged helpdesk failures in cyberattack

    Kandji helps secure Apple enterprise with Vulnerability Response

    Kandji helps secure Apple enterprise with Vulnerability Response

    Alibaba rolls out new AI coding model Qwen3-Coder, says it’s their most powerful

    Alibaba rolls out new AI coding model Qwen3-Coder, says it’s their most powerful

  • Gaming
    How to get the corrupt mutation in Grow a Garden

    How to get the corrupt mutation in Grow a Garden

    Is Gotham Knights As Bad As You Think?

    Is Gotham Knights As Bad As You Think?

    Stage 12 – Gungrave G.O.R.E PS5

    Stage 12 – Gungrave G.O.R.E PS5

    SUPER MARIO 3D WORLD – Trailer (Wii U)

    SUPER MARIO 3D WORLD – Trailer (Wii U)

    Assassin’s Creed : All Opening Title Intros (2007-2023)

    Assassin’s Creed : All Opening Title Intros (2007-2023)

    How this Film could be Incredible!!! | Super Mario Bros. Movie HOPES!

    How this Film could be Incredible!!! | Super Mario Bros. Movie HOPES!

    Hogwarts Legacy Review: Is it Worth the Hype?

    Hogwarts Legacy Review: Is it Worth the Hype?

    The Legion Go S SteamOS is completing the Steam Deck’s mission to make handheld PC gaming genuinely convenient

    Some lucky souls will get hands-on with Silksong within weeks, with the Hollow Knight sequel confirmed to be playable at Gamescom 2025

    The Division 2: Battle for Brooklyn DLC & Year 7 Showcase

    The Division 2: Battle for Brooklyn DLC & Year 7 Showcase

  • Retro Rewind
    Retro Rewind: Video Game Trader Winter 2014

    Retro Rewind: Video Game Trader Winter 2014

    Retro Rewind: Electronic Games April 1995

    Retro Rewind: Electronic Games April 1995

    Retro Rewind: Electronic Gaming Monthly Magazine Number 55 February 1994

    Retro Rewind: Electronic Gaming Monthly Magazine Number 57 April 1994

    Retro Rewind: Blast from the Past – 35 Iconic Commercials of 1988!

    Retro Rewind: Blast from the Past – 35 Iconic Commercials of 1988!

    Retro Rewind: PC World Magazine August 1998

    Retro Rewind: PC World Magazine August 1998

    Retro Rewind: Computer Shopper Magazine September 1997

    Retro Rewind: Computer Shopper Magazine September 1997

    Retro Rewind: PC Magazine December 2015

    Retro Rewind: PC Magazine December 2015

    Retro Rewind: EDGE Magazine RETRO #1: The Guide to Classic Videogame Playing and Collecting

    Retro Rewind: EDGE Magazine RETRO #1: The Guide to Classic Videogame Playing and Collecting

    Retro Rewind: Computer Gaming World Magazine Issue 73 December 1998

    Retro Rewind: Computer Gaming World Magazine Issue 73 December 1998

  • Tech Art
    3d spray wall painting flowers design || 3d wall paper wall painting || Freestyle artist sourav

    3d spray wall painting flowers design || 3d wall paper wall painting || Freestyle artist sourav

    03 EPIC Graphic Design Ideas in Photoshop – Full Tutorial

    03 EPIC Graphic Design Ideas in Photoshop – Full Tutorial

    How I Create AI Vector Files for Microstock | Step-by-Step for Adobe Stock & More

    How I Create AI Vector Files for Microstock | Step-by-Step for Adobe Stock & More

    5 Minute Drawing Lesson – digital illustration process explained

    5 Minute Drawing Lesson – digital illustration process explained

    How To Find Your Art Style (4 EASY WAYS) | Art Tips

    How To Find Your Art Style (4 EASY WAYS) | Art Tips

    Sarah D’Ambrosio: Brooklyn, Berlin

    Sarah D’Ambrosio: Brooklyn, Berlin

    WOOFIE SAD ORIGIN STORY?! The Amazing Digital Circus UNOFFICIAL Animation

    WOOFIE SAD ORIGIN STORY?! The Amazing Digital Circus UNOFFICIAL Animation

    Augmented Reality Fun with DoodleLens & PowerPoint

    Augmented Reality Fun with DoodleLens & PowerPoint

    Vector Art/ Vector Portrait Cartoon Effect Photoshop Action free Download

    Vector Art/ Vector Portrait Cartoon Effect Photoshop Action free Download

  • Tech Deals
    Western Digital 1TB WD Blue 3D NAND Internal PC SSD – SATA III 6 Gb/s, 2.5″/7mm, Up to…

    Western Digital 1TB WD Blue 3D NAND Internal PC SSD – SATA III 6 Gb/s, 2.5″/7mm, Up to…

    ICY BOX M.2 NVMe & SATA SSD/HDD Docking Station, USB-C 10 Gbps Dual Bay Hard Drive Clone…

    ICY BOX M.2 NVMe & SATA SSD/HDD Docking Station, USB-C 10 Gbps Dual Bay Hard Drive Clone…

    Apple iPad with WiFi, 32GB, Silver (2017 Model) (Renewed)

    Apple iPad with WiFi, 32GB, Silver (2017 Model) (Renewed)

    Veken 55 Inch Large Electric Standing Desk, 4 Memory Heights Adjustable,Sit to Stand Up,…

    Veken 55 Inch Large Electric Standing Desk, 4 Memory Heights Adjustable,Sit to Stand Up,…

    SM600 White Wireless Gaming Mouse,8000 DPI Tri-Modes BT5.1/Type-C Wired/2.4G Wireless…

    SM600 White Wireless Gaming Mouse,8000 DPI Tri-Modes BT5.1/Type-C Wired/2.4G Wireless…

    GTRACING Gaming Chair Racing Office Computer Ergonomic Video Game Chair Backrest and…

    GTRACING Gaming Chair Racing Office Computer Ergonomic Video Game Chair Backrest and…

    Rock Band – Nintendo Wii (Game only) (Renewed)

    Rock Band – Nintendo Wii (Game only) (Renewed)

    SanDisk 512GB Ultra Fit USB 3.2 Gen 1 Flash Drive – Up to 400MB/s, Plug-and-Stay Design…

    SanDisk 512GB Ultra Fit USB 3.2 Gen 1 Flash Drive – Up to 400MB/s, Plug-and-Stay Design…

    WD_BLACK 5TB P10 Game Drive, Portable External Hard Drive, Works with Playstation, Xbox,…

    WD_BLACK 5TB P10 Game Drive, Portable External Hard Drive, Works with Playstation, Xbox,…

  • Techs Got To Eat
    Strawberry Shortcake Mug Cake: In Minutes Your Summer Bliss Dessert

    Strawberry Shortcake Mug Cake: In Minutes Your Summer Bliss Dessert

    Molten Bacon Lasagna Mug: Crispy, Cheesy & Ready In 5 Minutes

    Molten Bacon Lasagna Mug: Crispy, Cheesy & Ready In 5 Minutes

    Bacon & Spinach Mug Quiche: 3-Minute Gourmet Breakfast

    Bacon & Spinach Mug Quiche: 3-Minute Gourmet Breakfast

    Cheesy Broccoli Rice Mug: 5-Minute Super Comfort Food

    Cheesy Broccoli Rice Mug: 5-Minute Super Comfort Food

    Top 10 Vegetarian Recipes for 2025: Easy and Nutritious Meals for Busy People

    Top 10 Vegetarian Recipes for 2025: Easy and Nutritious Meals for Busy People

    Bacon Mug Lasagna: 5-Minute Microwave Meat Lover’s Dream

    Bacon Mug Lasagna: 5-Minute Microwave Meat Lover’s Dream

    Bacon Fried Rice Mug: 5-Minute Microwave Meal

    Bacon Fried Rice Mug: 5-Minute Microwave Meal

    Bacon & Cheddar Mug Biscuit: 2-Minute Savory Comfort

    Bacon & Cheddar Mug Biscuit: 2-Minute Savory Comfort

    Loaded Bacon Cheesy Potato Mug: 5-Minute Comfort Food

    Loaded Bacon Cheesy Potato Mug: 5-Minute Comfort Food

  • Tesla
    BestEvMod 13PCS Speaker Cover Trim Kits Compatible with Tesla Cybertruck 2025 2024…

    BestEvMod 13PCS Speaker Cover Trim Kits Compatible with Tesla Cybertruck 2025 2024…

    Cartist Dash Cover Fit for Tesla Cybertruck 2024 2025 2026 Accessories Dashboard Cover…

    Cartist Dash Cover Fit for Tesla Cybertruck 2024 2025 2026 Accessories Dashboard Cover…

    Car Phone Holder, Car Center Console Dashboard Mobile Phone Holder, for Various…

    Car Phone Holder, Car Center Console Dashboard Mobile Phone Holder, for Various…

    2-in-1 CCS & J1772 to Tesla Adapter – 250KW Fast CCS to Tesla Adapter, Compatible with…

    2-in-1 CCS & J1772 to Tesla Adapter – 250KW Fast CCS to Tesla Adapter, Compatible with…

    TANDRIVE 2PCS Silicone Key Card Holder Case Compatible with Tesla Model 3 Model Y…

    TANDRIVE 2PCS Silicone Key Card Holder Case Compatible with Tesla Model 3 Model Y…

    Schumacher Electric SC1455 Level 2 Portable EV Charger – up to 16A, Works with 120V or 2…

    Schumacher Electric SC1455 Level 2 Portable EV Charger – up to 16A, Works with 120V or 2…

    Tesla inks $16.5B deal with Samsung for HW6 chips, but still no HW3 solution

    Tesla inks $16.5B deal with Samsung for HW6 chips, but still no HW3 solution

    2025 Upgraded for Tesla Supercharger to CCS Charger Adapter, Max 500A 1000V Fast Charge…

    2025 Upgraded for Tesla Supercharger to CCS Charger Adapter, Max 500A 1000V Fast Charge…

    Door Built-in Hidden Storage Box for Tesla Cybertruck 2024, Pop-Up Lid Door Side…

    Door Built-in Hidden Storage Box for Tesla Cybertruck 2024, Pop-Up Lid Door Side…

  • UFO
    Resident Alien: Season Two [DVD]

    Resident Alien: Season Two [DVD]

    Photoshop: How to Recreate a Vintage, UFO Sighting Photo!

    Photoshop: How to Recreate a Vintage, UFO Sighting Photo!

    UFO Encounters & Religion: Unexpected Spiritual Reinforcement

    UFO Encounters & Religion: Unexpected Spiritual Reinforcement

    GXCROR Sports Sun Visor Hat Men Women, Lightweight Breathable Quick-Dry Visor Hat, UPF 50+ Tennis Golf Running Visor

    GXCROR Sports Sun Visor Hat Men Women, Lightweight Breathable Quick-Dry Visor Hat, UPF 50+ Tennis Golf Running Visor

    UFOs Over Washington, D.C. (1952): The 'Invasion' That Shook the Nation

    UFOs Over Washington, D.C. (1952): The 'Invasion' That Shook the Nation

    UFOs: The Public Deceived

    UFOs: The Public Deceived

    Scientists Believe This Is an Alien?!

    Scientists Believe This Is an Alien?!

    Quetzalcoatl's True Origins | Ancient Aliens | #shorts

    Quetzalcoatl's True Origins | Ancient Aliens | #shorts

    FIRST CONTACTEE TRAINING WITH RIOK, ALAN STEINFELD, – ESP, Remote viewing, Channeling

    FIRST CONTACTEE TRAINING WITH RIOK, ALAN STEINFELD, – ESP, Remote viewing, Channeling

No Result
View All Result
Techcratic
No Result
View All Result
Home MIT Tech

MIT biologists discover a new type of control over RNA splicing | MIT News

MIT Tech by MIT Tech
February 20, 2025
in MIT Tech
Reading Time: 7 mins read
124
A A
0

Anne Trafton | MIT News
2025-02-20 05:00:00
news.mit.edu

RNA splicing is a cellular process that is critical for gene expression. After genes are copied from DNA into messenger RNA, portions of the RNA that don’t code for proteins, called introns, are cut out and the coding portions are spliced back together.

This process is controlled by a large protein-RNA complex called the spliceosome. MIT biologists have now discovered a new layer of regulation that helps to determine which sites on the messenger RNA molecule the spliceosome will target.

The research team discovered that this type of regulation, which appears to influence the expression of about half of all human genes, is found throughout the animal kingdom, as well as in plants. The findings suggest that the control of RNA splicing, a process that is fundamental to gene expression, is more complex than previously known.

“Splicing in more complex organisms, like humans, is more complicated than it is in some model organisms like yeast, even though it’s a very conserved molecular process. There are bells and whistles on the human spliceosome that allow it to process specific introns more efficiently. One of the advantages of a system like this may be that it allows more complex types of gene regulation,” says Connor Kenny, an MIT graduate student and the lead author of the study.

Christopher Burge, the Uncas and Helen Whitaker Professor of Biology at MIT, is the senior author of the study, which appears today in Nature Communications.

Building proteins

RNA splicing, a process discovered in the late 1970s, allows cells to precisely control the content of the mRNA transcripts that carry the instructions for building proteins.

Each mRNA transcript contains coding regions, known as exons, and noncoding regions, known as introns. They also include sites that act as signals for where splicing should occur, allowing the cell to assemble the correct sequence for a desired protein. This process enables a single gene to produce multiple proteins; over evolutionary timescales, splicing can also change the size and content of genes and proteins, when different exons become included or excluded.

The spliceosome, which forms on introns, is composed of proteins and noncoding RNAs called small nuclear RNAs (snRNAs). In the first step of spliceosome assembly, an snRNA molecule known as U1 snRNA binds to the 5’ splice site at the beginning of the intron. Until now, it had been thought that the binding strength between the 5’ splice site and the U1 snRNA was the most important determinant of whether an intron would be spliced out of the mRNA transcript.

In the new study, the MIT team discovered that a family of proteins called LUC7 also helps to determine whether splicing will occur, but only for a subset of introns — in human cells, up to 50 percent.

Before this study, it was known that LUC7 proteins associate with U1 snRNA, but the exact function wasn’t clear. There are three different LUC7 proteins in human cells, and Kenny’s experiments revealed that two of these proteins interact specifically with one type of 5’ splice site, which the researchers called “right-handed.” A third human LUC7 protein interacts with a different type, which the researchers call “left-handed.”

The researchers found that about half of human introns contain a right- or left-handed site, while the other half do not appear to be controlled by interaction with LUC7 proteins. This type of control appears to add another layer of regulation that helps remove specific introns more efficiently, the researchers say.

“The paper shows that these two different 5’ splice site subclasses exist and can be regulated independently of one another,” Kenny says. “Some of these core splicing processes are actually more complex than we previously appreciated, which warrants more careful examination of what we believe to be true about these highly conserved molecular processes.”

“Complex splicing machinery”

Previous work has shown that mutation or deletion of one of the LUC7 proteins that bind to right-handed splice sites is linked to blood cancers, including about 10 percent of acute myeloid leukemias (AMLs). In this study, the researchers found that AMLs that lost a copy of the LUC7L2 gene have inefficient splicing of right-handed splice sites. These cancers also developed the same type of altered metabolism seen in earlier work.

“Understanding how the loss of this LUC7 protein in some AMLs alters splicing could help in the design of therapies that exploit these splicing differences to treat AML,” Burge says. “There are also small molecule drugs for other diseases such as spinal muscular atrophy that stabilize the interaction between U1 snRNA and specific 5’ splice sites. So the knowledge that particular LUC7 proteins influence these interactions at specific splice sites could aid in improving the specificity of this class of small molecules.”

Working with a lab led by Sascha Laubinger, a professor at Martin Luther University Halle-Wittenberg, the researchers found that introns in plants also have right- and left-handed 5’ splice sites that are regulated by Luc7 proteins.

The researchers’ analysis suggests that this type of splicing arose in a common ancestor of plants, animals, and fungi, but it was lost from fungi soon after they diverged from plants and animals.

“A lot what we know about how splicing works and what are the core components actually comes from relatively old yeast genetics work,” Kenny says. “What we see is that humans and plants tend to have more complex splicing machinery, with additional components that can regulate different introns independently.”

The researchers now plan to further analyze the structures formed by the interactions of Luc7 proteins with mRNA and the rest of the spliceosome, which could help them figure out in more detail how different forms of Luc7 bind to different 5’ splice sites.

The research was funded by the U.S. National Institutes of Health and the German Research Foundation.

Source Link


Upgrade your audio game with the Logitech for Creators Blue Yeti USB Microphone. With over 33,730 ratings and an impressive 4.6 out of 5 stars, it’s no wonder this is an Amazon’s Choice product. Recently, 5K+ units were purchased in the past month.

Available in five stunning colors: Teal, Silver, Pink Dawn, Midnight Blue, and Blackout, this microphone is perfect for creators looking to produce exceptional audio. Priced at only $84.99, it’s a deal you can’t afford to miss.

Elevate your recordings with clear broadcast-quality sound and explore your creativity with enhanced effects, advanced modulation, and HD audio samples. Order now for just $84.99 on Amazon!


Unlock unlimited streaming with a free Amazon Prime trial!
Sign up today!

Help Power Techcratic’s Future – Scan To Support

If Techcratic’s content and insights have helped you, consider giving back by supporting the platform with crypto. Every contribution makes a difference, whether it’s for high-quality content, server maintenance, or future updates. Techcratic is constantly evolving, and your support helps drive that progress.

As a solo operator who wears all the hats, creating content, managing the tech, and running the site, your support allows me to stay focused on delivering valuable resources. Your support keeps everything running smoothly and enables me to continue creating the content you love. I’m deeply grateful for your support, it truly means the world to me! Thank you!

BITCOIN

Bitcoin Logo

Bitcoin QR Code

bc1qlszw7elx2qahjwvaryh0tkgg8y68enw30gpvge

Scan the QR code with your crypto wallet app

DOGECOIN

Dogecoin Logo

Dogecoin QR Code

D64GwvvYQxFXYyan3oQCrmWfidf6T3JpBA

Scan the QR code with your crypto wallet app

ETHEREUM

Ethereum Logo

Ethereum QR Code

0xe9BC980DF3d985730dA827996B43E4A62CCBAA7a

Scan the QR code with your crypto wallet app

Please read the Privacy and Security Disclaimer on how Techcratic handles your support.

Disclaimer: As an Amazon Associate, Techcratic may earn from qualifying purchases.

Tags: MIT Tech
Share162Share28ShareShare4ShareTweet101
MIT Tech

MIT Tech

Discover cutting-edge research and technological breakthroughs with MIT Tech. Explore innovative projects and academic insights shaping the future of technology. Stay informed with the latest articles here at Techcratic.

Related Posts

New system dramatically speeds the search for polymer materials | MIT News
MIT Tech

New system dramatically speeds the search for polymer materials | MIT News

July 28, 2025
1.3k
Famous double-slit experiment holds up when stripped to its quantum essentials | MIT News
MIT Tech

Famous double-slit experiment holds up when stripped to its quantum essentials | MIT News

July 28, 2025
1.3k
New machine-learning application to help researchers predict chemical properties | MIT News
MIT Tech

New machine-learning application to help researchers predict chemical properties | MIT News

July 24, 2025
1.3k
Theory-guided strategy expands the scope of measurable quantum interactions | MIT News
MIT Tech

Theory-guided strategy expands the scope of measurable quantum interactions | MIT News

July 24, 2025
1.3k
The unique, mathematical shortcuts language models use to predict dynamic scenarios | MIT News
MIT Tech

The unique, mathematical shortcuts language models use to predict dynamic scenarios | MIT News

July 21, 2025
1.3k
A major AI training data set contains millions of examples of personal data
MIT Tech

A major AI training data set contains millions of examples of personal data

July 18, 2025
1.3k
Model predicts long-term effects of nuclear waste on underground disposal systems | MIT News
MIT Tech

Model predicts long-term effects of nuclear waste on underground disposal systems | MIT News

July 18, 2025
1.3k
MIT’s Mason Estrada to sign with the Los Angeles Dodgers | MIT News
MIT Tech

MIT’s Mason Estrada to sign with the Los Angeles Dodgers | MIT News

July 17, 2025
1.3k
Load More
Next Post
Pick up M4 Pro Mac mini for $1,299 in Apple Reseller Price War

Pick up M4 Pro Mac mini for $1,299 in Apple Reseller Price War

Your Tech Resources

  • 30 Second Tech ™
  • AI
  • App Zone ™
  • Apple
  • Ars Technica
  • CNET
  • ComputerWorld
  • Crypto News
  • Cybersecurity
  • Endgadget
  • ExtremeTech
  • Forbes
  • Fossbytes
  • Gaming
  • GeekWire
  • Gizmodo
  • Google News
  • Hacker News
  • Harvard Tech
  • I Like Cats ™
  • I Like Dogs ™
  • LifeHacker
  • MacRumors
  • Macworld
  • Mashable
  • Microsoft
  • MIT Tech
  • PC World
  • Photofocus
  • Physics
  • Random Tech
  • Retro Rewind ™
  • Robot Report
  • SiliconANGLE
  • SlashGear
  • Smartphone
  • StackSocial
  • Tech Art
  • Tech Careers
  • Tech Deals
  • Techcratic ™
  • TechCrunch
  • Techdirt
  • TechRepublic
  • Techs Got To Eat ™
  • TechSpot
  • Tesla
  • The Verge
  • TNW
  • Trusted Reviews
  • UFO
  • VentureBeat
  • Visual Capitalist
  • Wired
  • ZDNet

Tech News

  • 30 Second Tech ™
  • AI
  • Apple Insider
  • Ars Technica
  • CNET
  • ComputerWorld
  • Crypto News
  • Cybersecurity
  • Endgadget
  • ExtremeTech
  • Fossbytes
  • Gaming
  • GeekWire
  • Gizmodo

Tech News

  • Harvard Tech
  • MacRumors
  • Macworld
  • Mashable
  • Microsoft
  • MIT Tech
  • Physics
  • PC World
  • Random Tech
  • Retro Rewind ™
  • SiliconANGLE
  • SlashGear
  • Smartphone
  • StackSocial
  • Tech Careers

Tech News​

  • Tech Art
  • TechCrunch
  • Techdirt
  • TechRepublic
  • Techs Got To Eat ™
  • TechSpot
  • Tesla
  • The Verge
  • TNW
  • Trusted Reviews
  • UFO
  • VentureBeat
  • Visual Capitalist
  • Wired
  • ZDNet

Site Links

  • About Techcratic
  • Affiliate Disclaimer
  • Affiliate Link Policy
  • Contact Techcratic
  • Dealors Discount Store
  • Privacy and Security Disclaimer
  • Privacy Policy
  • RSS Feed
  • Site Map
  • Support Techcratic
  • Techcratic
  • Tech Deals
  • TOS
  • 𝕏
Click For A Secret Deal

Here are 7 of my favorite back-to-school Chromebook deals, from ASUS to Lenovo

ESR MagMouse review: a wireless mouse that sticks to your MacBook

Western Digital 1TB WD Blue 3D NAND Internal PC SSD – SATA III 6 Gb/s, 2.5″/7mm, Up to…

Arena simulation platform designed to accelerate Gatik autonomous trucking

Google will struggle to make the Pixel 10 stand out if the camera isn’t king

iRobot’s Latest Roomba Will Keep Your Carpets Dry

Techcratic – Your All In One Tech Hub
© 2020 – 2025
All Rights Reserved
∞

No Result
View All Result
  • 30 Second Tech ™
  • AI
  • App Zone ™
  • Apple
  • Ars Technica
  • CNET
  • Crypto News
  • Cybersecurity
  • Endgadget
  • Gaming
  • MacRumors
  • Macworld
  • Retro Rewind ™
  • Tech Deals
  • Techcratic ™
  • Techs Got To Eat ™
  • Tesla
  • UFO
  • Visual Capitalist
  • Wired
  • ZDNet