10 Best Endpoint Protection Solutions for MSP/MSSPs in 2025

1. Palo Alto Networks

Why We Picked It:

Cortex XDR stands out for its ability to correlate data from various security layers, providing a holistic view of the threat landscape across a service provider’s entire client base.

This unified approach significantly enhances threat detection accuracy and accelerates incident response times, crucial for MSPs managing numerous diverse environments.

The multi-tenant portal is designed for efficient management and allows MSPs to offer sophisticated XDR services, adding significant value to their security offerings.

Specifications:

Cortex XDR integrates endpoint protection with network and cloud security data for extended detection and response.

Key features include AI-powered behavioral analytics, automated root cause analysis, managed threat hunting services (XDR Pro), and a multi-tenant portal for MSPs with role-based access control and centralized policy management.

Reason to Buy:

If you are an MSP/MSSP looking to offer advanced XDR capabilities that provide a unified view of threats across endpoints, networks, and clouds, Cortex XDR offers a powerful and integrated platform.

Its multi-tenancy and automation features are designed to streamline operations and enhance the value of your security services.

Features:

• Cross-Layer Detection: Correlates data from endpoints, networks, and clouds for broader threat visibility.
• AI-Powered Analytics: Uses machine learning to detect sophisticated and evasive threats.
• Automated Root Cause Analysis: Quickly identifies the origin and spread of attacks.
• Managed Threat Hunting (XDR Pro): Optional service providing proactive threat hunting by Palo Alto Networks experts.
• Multi-Tenant Portal: Streamlined management of multiple client environments with granular controls.

Pros:

• Comprehensive XDR capabilities from a leading security vendor.
• Enhanced threat detection and faster incident response.
• Multi-tenant architecture designed for MSPs.
• Opportunities to offer high-value managed security services.

Cons:

• Can be a more complex solution to deploy and manage initially.
• May require specialized expertise to fully leverage all features.

✅ Best For: MSPs/MSSPs seeking a comprehensive XDR platform to offer advanced threat detection, investigation, and response services across diverse client environments.

🔗 Try Palo Alto Networks (Cortex XDR) here → Palo Alto Networks Official Website

2. CrowdStrike Falcon

Why We Picked It:

CrowdStrike Falcon’s cloud-native design and single, lightweight agent simplify deployment and management across numerous endpoints, a significant advantage for MSPs.

Its industry-leading threat intelligence, powered by the CrowdStrike Threat Graph, provides unparalleled visibility into the global threat landscape, enabling proactive defense.

The platform’s robust APIs facilitate seamless integration with other MSP tools and workflows, enhancing operational efficiency.

Specifications:

CrowdStrike Falcon offers NGAV, EDR, threat intelligence, managed threat hunting (Falcon OverWatch), and vulnerability management, all delivered through a single, lightweight agent managed via a multi-tenant cloud console.

It features powerful search and investigation tools, as well as automated remediation capabilities.

Reason to Buy:

If your MSP/MSSP requires a high-performance, cloud-native endpoint protection platform with exceptional threat intelligence and seamless integration capabilities, CrowdStrike Falcon is a top contender.

Its scalability and robust feature set are well-suited for protecting a diverse range of client environments.

Features:

• Cloud-Native Architecture: Provides scalability, agility, and ease of management.
• Single, Lightweight Agent: Simplifies deployment and minimizes endpoint impact.
• CrowdStrike Threat Graph: Global threat intelligence network providing real-time insights.
• Falcon OverWatch: Optional managed threat hunting service for proactive threat detection.
• Robust APIs: Facilitate integration with other MSP tools and automation workflows.

Pros:

• Industry-leading threat detection and response capabilities.
• Lightweight agent with minimal performance overhead.
• Scalable cloud architecture for managing numerous clients.
• Strong partner program and support for MSPs.

Cons:

• Can be one of the more expensive endpoint protection solutions.
• Some advanced features may require specialized expertise to leverage fully.

✅ Best For: MSPs/MSSPs seeking a high-performance, cloud-native EDR platform with exceptional threat intelligence and robust integration capabilities.

🔗 Try CrowdStrike Falcon here → CrowdStrike Official Website

3. SentinelOne Singularity

Why We Picked It:

SentinelOne’s autonomous, AI-driven approach to endpoint security significantly reduces the reliance on traditional signature-based detection and enables real-time defense against both known and unknown threats.

Its unified Singularity platform provides a comprehensive view across various attack surfaces, simplifying management for MSPs.

The platform’s powerful automation and remediation capabilities minimize the need for manual intervention, enhancing operational efficiency for service providers.

Specifications:

SentinelOne Singularity offers AI-powered NGAV, EDR, XDR, and cloud workload protection through a single agent and a unified, multi-tenant management console.

Key features include behavioral AI for autonomous threat prevention, real-time threat hunting, and automated remediation with rollback capabilities.

Reason to Buy:

If your MSP/MSSP prioritizes an autonomous, AI-powered endpoint security solution that offers comprehensive protection across multiple attack surfaces and minimizes the need for manual intervention, SentinelOne Singularity is a leading choice.

Its unified platform and automation capabilities are well-suited for managing complex client environments efficiently.

Features:

• Autonomous AI Protection: Real-time prevention, detection, and response powered by behavioral AI.
• Unified Singularity Platform: Comprehensive security across endpoints, cloud, containers, and IoT.
• Single Agent: Simplifies deployment and management across diverse environments.
• Real-Time Threat Hunting: Enables proactive identification of advanced threats.
• Automated Remediation with Rollback: Automatically contains and reverses malicious activities.

Pros:

• Highly effective autonomous threat prevention and response.
• Unified platform provides broad visibility and control.
• Single agent simplifies deployment and management.
• Strong focus on innovation and future-ready security.

Cons:

• The advanced AI-powered features can have a steeper learning curve.
• Pricing models can be complex depending on the scale and features required.

✅ Best For: MSPs/MSSPs seeking an autonomous, AI-powered endpoint security platform that provides comprehensive protection and simplifies management across diverse attack surfaces.

🔗 Try SentinelOne Singularity here → SentinelOne Official Website

4. Sophos Intercept X

Why We Picked It:

Sophos Intercept X is a favorite among MSPs due to its comprehensive security features and the intuitive, purpose-built Sophos Central management console.

The platform’s deep learning capabilities provide excellent protection against both known and unknown malware, while its CryptoGuard anti-ransomware technology offers robust defense against ransomware attacks.

The synchronized security feature, which integrates with other Sophos products, enhances overall threat visibility and response.

Specifications:

Sophos Intercept X offers NGAV, EDR, anti-ransomware (CryptoGuard), exploit prevention, and deep learning-powered threat detection, all managed through the multi-tenant Sophos Central console.

It provides flexible licensing options and a strong partner program tailored for MSPs.

Reason to Buy:

If your MSP/MSSP requires a comprehensive and easy-to-manage endpoint protection solution with a strong track record and a dedicated partner program, Sophos Intercept X is an excellent option.

Its robust feature set and intuitive management console streamline operations and provide reliable security for a wide range of clients.

Features:

• Deep Learning Technology: Predictive threat prevention that identifies and blocks both known and unknown malware.
• CryptoGuard: Advanced anti-ransomware that prevents file encryption and rolls back malicious activity.
• Exploit Prevention: Blocks the techniques used in exploit attacks.
• Sophos Central: Unified, multi-tenant management console for all Sophos products.
• Synchronized Security: Integrates with Sophos firewalls for enhanced threat response.

Pros:

• Comprehensive security features in a single agent.
• Intuitive and robust multi-tenant management console.
• Strong partner program with excellent support for MSPs.
• Proven effectiveness against a wide range of threats, including ransomware.

Cons:

• Can be more expensive than some other solutions.
• The sheer number of features might be overwhelming for very small MSPs or clients.

✅ Best For: MSPs/MSSPs seeking a comprehensive, easy-to-manage endpoint protection solution with a strong partner program and proven effectiveness against diverse threats.

🔗 Try Sophos Intercept X here → Sophos Official Website

5. Trellix

Why We Picked It:

Trellix combines the extensive threat intelligence and endpoint security legacy of McAfee with the advanced threat detection and incident response expertise of FireEye.

This union creates a powerful endpoint protection platform capable of addressing a wide spectrum of threats, from commodity malware to sophisticated advanced persistent threats (APTs).

For MSPs, Trellix offers a multi-tenant management platform and flexible licensing options to cater to diverse client needs.

Specifications:

Trellix Endpoint Security offers NGAV, EDR, endpoint firewall, and threat intelligence, managed through a unified multi-tenant cloud console.

Key features include machine learning-powered threat detection, behavioral analysis, exploit prevention, and integrated threat intelligence feeds.

Reason to Buy:

If your MSP/MSSP requires a comprehensive endpoint protection platform backed by the combined expertise and threat intelligence of McAfee and FireEye, Trellix offers a robust solution.

Its breadth of features and multi-tenant management capabilities are designed to meet the diverse security needs of your client base.

Features:

• Combined Expertise: Leverages the strengths of McAfee and FireEye.
• Comprehensive Endpoint Security: Offers NGAV, EDR, and endpoint firewall in a single agent.
• Advanced Threat Intelligence: Integrated threat feeds from both McAfee and FireEye.
• Machine Learning and Behavioral Analysis: Detects known and unknown threats.
• Multi-Tenant Cloud Console: Centralized management for multiple client environments.

Pros:

• Broad range of security features from two established vendors.
• Strong threat intelligence and detection capabilities.
• Multi-tenant management designed for MSPs.
• Flexible licensing options.

Cons:

• The integration of the two legacy platforms is ongoing and may have complexities.
• Brand recognition for Trellix is still developing.

✅ Best For: MSPs/MSSPs looking for a comprehensive endpoint protection platform backed by the combined legacy and expertise of McAfee Enterprise and FireEye.

🔗 Try Trellix here → Trellix Official Website

6. Microsoft Defender

Why We Picked It:

For MSPs and MSSPs with a client base heavily invested in the Microsoft ecosystem, Microsoft Defender for Endpoint offers a powerful and often cost-effective security solution.

Its deep integration with Windows 10 and 11, along with other Microsoft security services, provides a unified and streamlined security experience.

While direct multi-tenancy management has been a past challenge, Microsoft has made significant strides in enabling MSPs to manage multiple client tenants through the Microsoft 365 Lighthouse portal.

Specifications:

Microsoft Defender for Endpoint offers NGAV, EDR, threat and vulnerability management, and automated investigation and response capabilities tightly integrated with the Windows operating system and managed through the Microsoft 365 Defender portal (and Microsoft 365 Lighthouse for MSPs).

Reason to Buy:

If your MSP/MSSP primarily serves clients deeply entrenched in the Microsoft ecosystem, Microsoft Defender for Endpoint offers a powerful, integrated, and often cost-effective endpoint security solution.

The deep integration simplifies deployment and management within Microsoft environments.

Features:

• Deep Windows Integration: Seamlessly integrated into the operating system.
• Comprehensive Security Stack: Offers NGAV, EDR, and vulnerability management.
• Automated Investigation and Response: Automatically investigates and remediates threats.
• Microsoft Threat Intelligence: Leverages a vast global threat intelligence network.
• Microsoft 365 Lighthouse: Provides multi-tenant management capabilities for MSPs.

Pros:

• Powerful and comprehensive security capabilities.
• Deep integration with the Microsoft ecosystem.
• Often included within Microsoft 365 subscriptions.
• No separate agent installation required for Windows 10/11.

Cons:

• Management for non-Microsoft endpoints can be less streamlined.
• Multi-tenancy management through Lighthouse, while improving, may not be as mature as dedicated MSP platforms.
• Licensing can be complex to navigate for MSPs.

✅ Best For: MSPs/MSSPs primarily managing clients heavily invested in the Microsoft ecosystem seeking a powerful and integrated endpoint security solution.

🔗 Try Microsoft Defender here → Microsoft Defender Official Website

7. Bitdefender GravityZone

Why We Picked It:

Bitdefender GravityZone for MSPs stands out for its highly effective, multi-layered security engine that consistently performs well in independent tests.

Its lightweight agent ensures minimal performance impact on client endpoints, a crucial factor for MSPs supporting diverse hardware environments.

The platform’s flexible, usage-based pricing model and centralized, multi-tenant cloud console make it an attractive and cost-effective option for service providers.

Specifications:

Bitdefender GravityZone for MSPs offers NGAV, EDR, advanced threat security, and endpoint risk management, managed through a multi-tenant cloud console with flexible monthly licensing based on consumption.

Reason to Buy:

If your MSP/MSSP prioritizes a high-performance, effective endpoint security solution with a low system footprint and a flexible, MSP-centric pricing model, Bitdefender GravityZone is an excellent choice.

Its layered security approach provides robust protection without impacting client device performance.

Features:

• High-Performance Security Engine: Consistently ranks high in independent security tests.
• Multi-Layered Protection: Combines signature-based and advanced behavioral analysis.
• Lightweight Agent: Minimal impact on endpoint performance.
• GravityZone Cloud Console: Centralized, multi-tenant management with granular controls.
• Flexible MSP Licensing: Usage-based monthly billing.

Pros:

• Highly effective threat detection with low false positives.
• Minimal impact on system performance.
• Flexible and cost-effective MSP pricing model.
• Easy to deploy and manage through the cloud console.

Cons:

• Some advanced features may require additional modules or expertise.
• User interface, while functional, may not be as modern as some competitors.

✅ Best For: MSPs/MSSPs seeking a high-performance, lightweight endpoint security solution with a flexible, MSP-friendly pricing model.

🔗 Try Bitdefender GravityZone here → Bitdefender Official Website

8. ESET Protect

Why We Picked It:

ESET Protect is favored by MSPs for its reliable threat detection, low system impact, and highly configurable management capabilities.

The ESET PROTECT platform offers a single pane of glass for managing security across all client endpoints, with granular control over policies and reporting.

ESET’s long-standing reputation for security excellence and its dedicated MSP program provide a solid foundation for service providers.

Specifications:

ESET Protect offers NGAV, anti-malware, anti-spyware, ransomware protection, and optional EDR capabilities, managed through the cloud-based ESET PROTECT platform.

It features flexible licensing options, detailed reporting, and robust policy management tailored for MSPs.

Reason to Buy:

If your MSP/MSSP requires a highly customizable and reliable endpoint security platform with a low system footprint and robust multi-tenant management, ESET Protect is a strong contender.

Its balance of detection efficacy and performance makes it suitable for a wide range of client environments.

Features:

• Proven Detection Technology: Consistently high scores in independent tests.
• Low System Footprint: Minimal impact on endpoint performance.
• ESET PROTECT Platform: Centralized, multi-tenant management console.
• Highly Customizable Policies: Granular control over security settings.
• Dedicated MSP Program: Tailored support and resources for service providers.

Pros:

• Reliable and effective threat detection.
• Lightweight agent with minimal resource consumption.
• Flexible and customizable management platform.
• Strong MSP partner program and support.

Cons:

• The user interface can sometimes feel less intuitive than more modern platforms.
• Advanced EDR features may require additional configuration and expertise.

✅ Best For: MSPs/MSSPs seeking a highly customizable and reliable endpoint security platform with a low system footprint and robust multi-tenant management.

🔗 Try ESET Protect here → ESET Official Website

9. Kaspersky

Why We Picked It:

Kaspersky Endpoint Security is recognized for its powerful and multi-layered threat detection engine, effectively safeguarding endpoints against a wide range of cyber threats.

Its comprehensive feature set, including endpoint control, web control, and vulnerability assessment, provides MSPs with a holistic security solution for their clients.

Kaspersky’s robust partner program and multi-tenant management console cater specifically to the needs of service providers.

Specifications:

Kaspersky Endpoint Security offers NGAV, EDR, endpoint hardening, web and device control, vulnerability and patch management, and anti-ransomware capabilities, managed through the Kaspersky Security Center console, which supports multi-tenancy for MSPs.

Reason to Buy:

If your MSP/MSSP requires a feature-rich endpoint security solution with a strong emphasis on threat detection and comprehensive endpoint control capabilities, Kaspersky Endpoint Security is a solid choice.

Its robust feature set provides a holistic approach to endpoint protection for diverse client environments.

Features:

• Strong Threat Detection: Multi-layered protection against a wide range of threats.
• Endpoint Control: Manages device access, application usage, and web browsing.
• Vulnerability and Patch Management: Identifies and remediates software vulnerabilities.
• Kaspersky Security Center: Scalable management console with multi-tenancy support.
• Robust Partner Program: Offers dedicated resources and support for MSPs.

Pros:

• Highly effective threat detection engine.
• Comprehensive set of security features.
• Scalable management console for MSPs.
• Strong focus on business security.

Cons:

• Geopolitical considerations may be a concern for some clients.
• The management console can be complex to navigate initially.

✅ Best For: MSPs/MSSPs seeking a feature-rich endpoint security solution with strong threat detection and comprehensive endpoint control capabilities.

🔗 Try Kaspersky Endpoint Security here → Kaspersky Official Website

10. Trend Micro

Why We Picked It:

Trend Micro Apex One provides a comprehensive endpoint security solution with a strong emphasis on threat prevention and detection.

Its layered security approach, incorporating machine learning, behavioral analysis, and vulnerability protection, offers robust defense against diverse threats.

The platform’s multi-tenant console and flexible deployment options cater well to the operational needs of MSPs managing multiple client environments.

Specifications:

Trend Micro Apex One offers NGAV, behavioral analysis, exploit prevention, endpoint detection and response (EDR), and vulnerability protection, managed through a centralized, multi-tenant console.

It provides flexible deployment options (cloud, on-premises, hybrid) and a robust partner program for MSPs.

Reason to Buy:

If your MSP/MSSP requires a comprehensive endpoint security platform with a layered approach to threat prevention and detection, along with flexible deployment and multi-tenant management, Trend Micro Apex One is a viable option.

Its breadth of features and established presence in the security market make it a reliable choice.

Features:

• Layered Security Approach: Combines traditional and advanced threat detection techniques.
• Behavioral Analysis: Detects and blocks malicious behavior.
• Exploit Prevention: Protects against software vulnerabilities.
• Endpoint Detection and Response (EDR): Provides visibility and response capabilities.
• Multi-Tenant Management: Centralized console for managing multiple clients.

Pros:

• Comprehensive set of security features.
• Flexible deployment options.
• Strong threat prevention and detection capabilities.
• Established and reputable security vendor.

Cons:

• The user interface can sometimes feel dated compared to newer platforms.
• EDR capabilities may not be as deeply integrated as some purpose-built EDR solutions.

✅ Best For: MSPs/MSSPs seeking a comprehensive endpoint security platform with a layered approach to threat prevention and flexible deployment options.

🔗 Try Trend Micro Apex One here → Trend Micro Official Website

Conclusion

Selecting the optimal endpoint protection solution is a critical decision for MSPs and MSSPs in 2025.

The ideal choice will not only provide robust security for their clients but also align with their operational efficiency, scalability needs, and profitability goals.

The top 10 solutions highlighted in this article each offer unique strengths and capabilities, from the comprehensive XDR of Palo Alto Networks Cortex to the cloud-native agility of CrowdStrike Falcon, the autonomous AI of SentinelOne, and the MSP-centric design of Bitdefender GravityZone and Sophos Intercept X.

Ultimately, the best endpoint protection solution for your MSP/MSSP will depend on a careful evaluation of your specific client needs, technical expertise, budget considerations, and strategic goals.

By thoroughly understanding the features, benefits, and potential drawbacks of each of these leading platforms, service providers can make an informed decision that will empower them to deliver exceptional endpoint security services and solidify their position as trusted cybersecurity partners in the evolving threat landscape of 2025.